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本研究通过合成寡核苷酸构建训练数据集，欧博娱乐开发了基于纳米孔测序的深度学习模型，首次实现8-oxo-dG的单核苷酸分辨率直接检测。在诱导氧化应激的细胞模型中，欧博allbet发现8-oxo-dG在基因组中分布不均且与5-mC存在互作关系，为理解氧化损伤导致的突变机制和表观遗传调控提供了新见解。 (责任编辑：) |
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本研究通过合成寡核苷酸构建训练数据集，欧博娱乐开发了基于纳米孔测序的深度学习模型，首次实现8-oxo-dG的单核苷酸分辨率直接检测。在诱导氧化应激的细胞模型中，欧博allbet发现8-oxo-dG在基因组中分布不均且与5-mC存在互作关系，为理解氧化损伤导致的突变机制和表观遗传调控提供了新见解。 (责任编辑：) |
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